Bilateral Phrenic Neuropathy
Electrophysiologic testing demonstrated ac tive denervation restricted to the diaphragm.
Bilateral phrenic neuropathy. Bilateral isolated phrenic neuropathy causing painless bilateral diaphragmatic paralysis abstract the authors report four patients with a syndrome of painless bilat eral isolated phrenic neuropathy. Vocal cord and diaphragm paralysis as clinical features of a french family with autosomal recessive charcot marie tooth disease associated with a new mutation in the gdap1 gene. Dyspnea as the predominant manifestation of bilateral phrenic neuropathy. The authors conclude that bilateral isolated phrenic neuropathy is a cause of painless diaphragmatic paralysis distinguishable from immune brachial plexus neuropathy and other neuromuscular disorders with similar clinical presentation.
The aetiology of phrenic neuropathy is often unknown but immune mechanisms may play a role. Clinical examination ultrasound and nerve conduction studies confirmed the bilateral involvement of the phrenic nerves. Phrenic neuropathy may be an important albeit a rare complication of diabetes and hence diaphragmatic dysfunction associated with diabetic phrenic neuropathy should be considered in any patient with unexplained breathlessness orthopnea and respiratory failure. Mayo clin proc 2004.
Long term recovery was poor. Bilateral phrenic nerve neuropathy mfw mar 01 2001 what is the etiology of bilateral phrenic nerve paralysis.